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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WEE1
All Species:
14.55
Human Site:
S122
Identified Species:
24.62
UniProt:
P30291
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30291
NP_003381.1
646
71597
S122
E
E
E
G
F
G
S
S
S
P
V
K
S
P
A
Chimpanzee
Pan troglodytes
XP_521839
646
71607
S122
E
E
E
G
F
G
S
S
S
P
V
K
S
P
A
Rhesus Macaque
Macaca mulatta
NP_001099016
568
63102
P77
W
E
K
D
N
E
S
P
D
Q
I
L
R
T
P
Dog
Lupus familis
XP_534051
887
95991
S363
E
E
E
G
F
G
S
S
S
P
V
K
S
P
A
Cat
Felis silvestris
Mouse
Mus musculus
P47810
646
71560
S121
W
E
E
E
G
F
G
S
S
S
P
V
K
S
P
Rat
Rattus norvegicus
Q63802
646
71478
S122
E
E
E
G
F
G
S
S
S
P
V
K
S
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510171
572
63943
A81
G
G
D
A
S
P
R
A
R
P
P
P
D
A
S
Chicken
Gallus gallus
NP_001026352
641
70947
G118
S
S
P
V
K
S
P
G
A
Y
F
T
A
G
S
Frog
Xenopus laevis
P47817
555
61670
P63
R
N
E
R
E
L
S
P
T
Q
E
L
S
P
S
Zebra Danio
Brachydanio rerio
NP_001005770
612
68517
P109
S
P
S
P
R
K
S
P
P
A
Y
D
S
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P54350
609
68790
Q110
A
T
P
K
T
I
L
Q
K
S
T
T
Q
C
S
Honey Bee
Apis mellifera
XP_624069
589
66032
C98
I
P
P
R
E
N
I
C
S
Q
K
I
S
M
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999796
624
68925
A117
M
V
C
A
S
S
P
A
S
S
A
G
G
G
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L4H0
500
56512
L9
F
E
K
N
G
R
T
L
L
A
K
R
K
T
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
42.1
70.9
N.A.
90.5
91.6
N.A.
72.7
80.1
42.8
64.2
N.A.
36.5
41.6
N.A.
39.6
Protein Similarity:
100
99.8
56.1
71.3
N.A.
92.7
93.1
N.A.
79.2
85.9
55.2
75
N.A.
54.1
59.2
N.A.
55.5
P-Site Identity:
100
100
13.3
100
N.A.
26.6
93.3
N.A.
6.6
0
26.6
13.3
N.A.
0
20
N.A.
6.6
P-Site Similarity:
100
100
26.6
100
N.A.
26.6
93.3
N.A.
26.6
20
40
13.3
N.A.
6.6
20
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
23
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
15
0
0
0
15
8
15
8
0
8
8
29
% A
% Cys:
0
0
8
0
0
0
0
8
0
0
0
0
0
8
0
% C
% Asp:
0
0
8
8
0
0
0
0
8
0
0
8
8
0
8
% D
% Glu:
29
50
43
8
15
8
0
0
0
0
8
0
0
0
0
% E
% Phe:
8
0
0
0
29
8
0
0
0
0
8
0
0
0
0
% F
% Gly:
8
8
0
29
15
29
8
8
0
0
0
8
8
15
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
8
8
0
0
0
8
8
0
0
0
% I
% Lys:
0
0
15
8
8
8
0
0
8
0
15
29
15
0
0
% K
% Leu:
0
0
0
0
0
8
8
8
8
0
0
15
0
0
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
8
0
8
8
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
15
22
8
0
8
15
22
8
36
15
8
0
36
22
% P
% Gln:
0
0
0
0
0
0
0
8
0
22
0
0
8
0
8
% Q
% Arg:
8
0
0
15
8
8
8
0
8
0
0
8
8
0
0
% R
% Ser:
15
8
8
0
15
15
50
36
50
22
0
0
50
15
29
% S
% Thr:
0
8
0
0
8
0
8
0
8
0
8
15
0
15
8
% T
% Val:
0
8
0
8
0
0
0
0
0
0
29
8
0
0
0
% V
% Trp:
15
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _